Manufacturing
SM Biomed Sdn. Bhd. is a R&D backed API and Intermediates manufacturing company and also the first and largest USFDA approved API manufacturing facility in Malaysia.
We have two fully equipped production blocks in the premises. Plant-I dedicated for Macrolide antibiotics and Plant-II a multi-product facility with functional utilities including Steam, Chilled Water, Cooling water, Vacuum and Compressed air and multiple clean rooms.
Each of our facilities was built with quality, operational adaptability, and manufacturing capabilities in mind. With these attributes at our core, SM offers prompt production slots and uncompromising quality.
Plant-I
- Dedicated facility for Macrolide antibiotics
- Installed reactor capacity: 23.5KL
- Annual production capacity: 200 MT
- ISO Class 8 classified finishing area (Class 100,000 area)
Plant-II (Multipurpose Production Facility)
- Multipurpose production facility offering greater flexibility
- Specific production areas to handle different products
- Ground +2 storey facility
- Temperature capability: -80°C to +180°C
- ISO Class 8 classified finishing area (Class 100,000 area)
Reaction Capabilities
| Reaction Capabilities | Reagent Capabilities |
|---|---|
| Grignard Reaction | RMgX |
| Chiral Reduction | S-CBS Reagent |
| Chemical Resolution | (+)-CSA, L-(+)-Tartaric acid |
| Organoborane Chemistry | Borane-Dimethyl Methyl Sulphate |
| Chlorination | POCl3, HCl |
| Bromination | Bromine / HBr in Acetic Acid, NBS, DBH |
| Nitration | HNO3 / H2SO4 |
| Reductive Amination | Formic acid, Formaldehyde |
| Reduction | NaBH4, K2BH4, LiAlH4 |
| Cyclization | Acylating reagent / AlCl3 |
| Friedel Crafts Reaction | AlCl3 |
| Wittig Reaction | Methyltriphenylphosphonium Bromide |
| Mesylation / Tosylation | Methanesulfonyl Chloride, Para-Toluene Sulfonylchloride |
| Methylation | MeI/KOH, Dimethyl Sulphate / CaCO3 |
| Demethylation | N-Demethylation using Sodium acetate / I2, BBr3 |
| Condensation Reaction | EDCI / HOBT |